Blood metabolome predicts gut microbiome α-diversity in humans
- Study the reflection of gut microbiome in the bloodstream
- Find blood biomarkers for low, potentially problematic, gut microbiome diversity
- Study the complex interconnections between host metabolism, gut microbial composition, and human health.
The microbes in our gut are important to our health, but we do not yet know how to tell if a particular mix of microbes is “healthy”. We have found that gut microbiome diversity is strongly reflected in its host by a small subset of blood metabolites, which may lead to clinical tests to monitor the health of our gut’s tenants. We believe that the key to defining and monitoring a healthy state of the microbiome is examining its reflection in the blood, which may be more stable, quantifiable, and universal.
Blood metabolome predicts gut microbiome α-diversity in humans. Wilmanski T, Rappaport N, Earls JC, Magis AT, Manor O, Lovejoy J, Omenn GS, Hood L, Gibbons SM, Price ND. Nat Biotechnol. 2019 Oct;37(10):1217-1228. doi: 10.1038/s41587-019-0233-9. Epub 2019 Sep 2. PMID:31477923
Learn more in the “behind the paper” post https://bioengineeringcommunity.nature.com/users/297617-noa-rappaport/posts/52687-the-reflection-of-gut-microbiota-in-the-bloodstream
Key Project Personnel:
|Tomasz Wilmanski||Noa Rappaport||Nathan Price|