Longevity research represents an enormous opportunity to help improve ‘healthspan’ of the aging population. The proportion of older people in the developed world is growing at rates never seen before. The NIA funded Longevity Consortium seeks to understand factors mediating longevity, health-span and age-related disease and Dr. Nathan Price is the Principal Investigator of the Systems Biology Core component. The Systems Biology Core supports the integration and analysis of high dimensional data across the consortium, including genomics, metabolomics, proteomics, transcriptomics from humans and animal models.
Patterns of Healthy Aging in the Gut Microbiome
Objectives: Characterize ‘healthy/unhealthy aging’ trajectories from the perspective of the gut microbiome across the adult human lifespan. Investigate changes in gut microbiome composition predictive of mortality and longevity in elderly populations. Study the reflection of the identified gut microbiome aging patterns in host physiology, primarily through blood analytes. Summarizing paragraph: Despite considerable progress in understanding the human gut microbiome, very little is known about how gut microbial changes across age…
Biological Age, derived from molecular and physiological measurements, has been proposed to better predict mortality and disease than chronological age. We have leveraged longitudinal deep phenotyping data from a real world cohort to develop a computed estimate of biological age. In our studies, biological age relative to chronological age, was elevated in the presence of chronic disease, providing evidence for the value of our approach. Since biological age is modifiable,…