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The Hood-Price Lab for Systems Biomedicine
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A New Approach to Alzheimer’s Disease
The impact of Alzheimer’s Disease is staggering – 6 million Americans diagnosed, a financial toll of $600 billion annually, and no effective drug treatments. ISB Co-founder Dr. Lee Hood said the traditional approach isn’t working, and we need to think about it in brand new ways.
David Sinclair On Why We Age — And Why We Don’t Have To
Dr. David Sinclair, a Harvard Medical School professor and New York Times bestselling author, was the guest of honor for the ISB-Town Hall Science Series on Thursday. He joined genomics pioneer and ISB Co-founder Dr. Lee Hood for a conversation that covered the very latest in aging research.
ISB Research on the Aging Microbiome Featured in The New York Times
ISB’s research into the aging microbiome was featured in a story published by Anahad O’Connor for The New York Times titled “A Changing Gut Microbiome May Predict How Well You Age.” The research featured was published in Nature Metabolism by Drs. Tomasz Wilmanksi, Noa Rappaport, Sean Gibbons and Nathan Price.
COVID-19 Outcome Disparities Across Racial/Ethnic Lines
ISB researchers and their collaborators looked at the electronic health records of nearly 630,000 patients who were tested for SARS-CoV-2, and found stark disparities in COVID-19 outcomes — odds of infection, hospitalization, and in-hospital mortality — between White and non-White minority racial and ethnic groups.
Gut Microbiome Implicated in Healthy Aging and Longevity
The gut microbiome is an integral component of the body, but its importance in the human aging process is unclear. ISB researchers and their collaborators have identified distinct signatures in the gut microbiome that are associated with either healthy or unhealthy aging trajectories, which in turn predict survival in a population of older individuals.
Drs. Anthony Fauci, Lee Hood Talk COVID-19, Vaccines, Future of Research, More
NIAID Director Dr. Anthony Fauci sat down for a conversation with ISB’s Dr. Lee Hood. The renowned scientists spoke about the importance of basic research, the extraordinary speed of COVID research, the efficacy of mRNA vaccines on COVID-19, lessons learned from the COVID-19 pandemic, and much more.
Bile Acids Provide More Evidence of the Gut Microbiome’s Effect on Alzheimer’s Disease
ISB researchers and their collaborators are looking beyond the one-drug, one-solution approach that has thus far failed in Alzheimer’s disease research. Instead, they are focusing on other promising research avenues, such as the possible role of the gut microbiome in dementia.
Variations in the Microbiome Associated with Health, Disease
ISB researchers examined the associations between the gut microbiomes of about 3,400 people and roughly 150 host characteristics. The team looked at diet, medication use, clinical blood markers, and other lifestyle and clinical factors, and found evidence that variations of the gut microbiome are associated with health and disease.
ISB Researchers Identify Signals of Metastatic Cancer Years Prior to Diagnosis
By analyzing blood plasma samples taken at several time points, ISB researchers have identified specific proteins that persistently presented as outliers and signaled metastatic cancer well before patients were diagnosed. The findings were published in the journal Scientific Reports.