Research

  • Cancer

    Complex diseases like cancers are heterogeneous (unique both within and across individuals) and dynamic (changing over time) diseases that arise from perturbations to multiple biological networks at different levels of organization. One of the ways we profile multiple systems at once is using various -omic technologies to profile an individual in many different ways. The central idea is that we need to personalize our treatments to each individual. Ultimately, we…

  • Infectious Disease & Biomarker Discovery

    Infectious Disease research projects involve the discovery of biomarkers to improve diagnosis and identify potential therapeutic targets. Current projects underway in the laboratory, focused include research efforts in Lyme Disease, Sepsis and Influenza. Lyme Disease Incidence has doubled over the past few decades with ~30,000 confirmed new case per year, which is likely an underestimate due to undiagnosed disease. Current diagnostic tests are only effective several weeks after infection since…

  • Pregnancy Health

    Pregnancy Health is an active area of supported research in the lab. We use high dimensional multi-omic data to map molecular networks to understand normal pregnancy as well as changes associated with complications in an effort to identify risk factor and predict abnormal pregnancies well in advance of currently possible in the clinic. We have several on-going projects with both federal and private support, including: Harnessing “omics”: A Systems Biology approach…

  • PD3 Clouds & Computational Methods

    Personal, Dense, Dynamic Data (PD3) Clouds are a central resource of the lab in the support of scientific wellness, P4 healthcare and disease studies. Initial focus has been on the collection genomic, metabolomic, proteomic and gut microbiomic data, along with digital health measures from wearables and lifestyle questionnaires. However, in principal, any longitudinal data collected from individuals can be incorporated PD3 clouds to contribute to the global quantification and understanding…

  • Scientific Wellness

    Scientific Wellness is a major focus of the lab and leverages PD3 clouds to quantify and define wellness and identify deviations from well states toward disease and asserts that biology is an informational science. Scientific Wellness embodies the personalization of health and is related to P4 Healthcare, which focuses on the clinical delivery of scientific wellness concepts. All of us are unique due to the interactions between our genetics (relatively…

  • Longevity

    Longevity research represents an enormous opportunity to help improve ‘healthspan’ of the aging population. The proportion of older people in the developed world is growing at rates never seen before. The NIA funded Longevity Consortium seeks to understand factors mediating longevity, health-span and age-related disease and Dr. Nathan Price is the Principal Investigator of the Systems Biology Core component. The Systems Biology Core supports the integration and analysis of high…

  • P4 Healthcare & the 1MGxPx Project

    P4 Healthcare is Personalized, Predictive, Preventative and Participatory. Dr. Hood is the Chief Science Officer in the Providence St. Joseph Healthcare system (a 51 hospital system in the western United States), and we are leveraging this relationship to implement 21st century medicine. P4 healthcare uses genomics and deep longitudinal phenotyping (e.g. metabolomics, proteomics, microbiomics) to understand global risk factors for each individual and identify wellness to disease transitions at the…

  • Alzheimer’s Disease & Brain Health

    Alheimer’s Disease and Brain Health is an active area of research in our lab. Alzheimer’ Disease is the 6th leading cause of death in the US, with a high financial and health burden on sufferers and family caregivers and, astonishingly, over 400 drug trials have essentially failed to treat the disease. We focus on the molecular neurochemistry of Alzheimer’s Disease with funding from the NIA through the AMP-AD consortium (Accelerating…