Scientific Wellness

Scientific Wellness is a major focus of the lab and leverages PD3 clouds to quantify and define wellness and identify deviations from well states toward disease and asserts that biology is an informational science. Scientific Wellness embodies the personalization of health and is related to P4 Healthcare, which focuses on the clinical delivery of scientific wellness concepts. All of us are unique due to the interactions between our genetics (relatively static) and our environment (relatively dynamic), which includes lifestyle choices. These interactions are manifested in the dynamics of molecular, biochemical and physiological networks and contribute to homeostatic maintenance of health or divergence toward disease. Conceptually, longitudinal studies using high dimensional data (e.g. genetics, metabolomics, proteomics, microbiomics) can deeply evaluate individual phenotypes to define healthy and identify prodromal deviations from health, well in advance of clinical symptoms. This work is fostering the invention new analytical approaches, new concepts in health and data space, and discovering new insights into human biology.

Recent papers describing this work, include:

Blood metabolome predicts gut microbiome α-diversity in humans. Wilmanski T, Rappaport N, Earls JC, Magis AT, Manor O, Lovejoy J, Omenn GS, Hood L, Gibbons SM, Price ND. Nat Biotechnol. 2019 Oct;37(10):1217-1228. doi:10.1038/s41587-019-0233-9. Epub 2019 Sep 2. PubMed PMID: 31477923

MicroRNA-transcriptome networks in whole blood and monocytes of women undergoing 

preterm labour. Paquette AG, Shynlova O, Wu X, Kibschull M, Wang K, Price ND, Lye SJ. J Cell Mol Med. 2019 Oct;23(10):6835-6845. doi:10.1111/jcmm.14567. Epub 2019 Jul 24. PubMed PMID: 31342622

Blood Is a Window into Health and Disease. Yurkovich JT, Hood L. Clin Chem. 2019 Oct;65(10):1204-1206. doi: 10.1373/clinchem.2018.299065. Epub 2019 Jun 6. PubMed PMID: 31171530

Genetic Predisposition Impacts Clinical Changes in a Lifestyle Coaching Program. Zubair N, Conomos MP, Hood L, Omenn GS, Price ND, Spring BJ, Magis AT, Lovejoy JC. Sci Rep. 2019 May 2;9(1):6805. doi: 10.1038/s41598-019-43058-0. PubMed PMID: 31048771; PubMed Central PMID: 31048771

Temporal transcriptomic analysis of metabolic genes in maternal organs and placenta during murine pregnancy. Paquette A, Baloni P, Holloman AB, Nigam S, Bammler T, Mao Q, Price ND. Biol Reprod. 2018 Dec 1;99(6):1255-1265. Doi:10.1093/biolre/ioy148. PMID: 29939228

Prevent Prematurity and Stillbirth Systems Biology of Preterm Birth Team. Comparative analysis of gene expression in maternal peripheral blood and monocytes during spontaneous preterm labor.  Paquette AG, Shynlova O, Kibschull M, Price ND, Lye SJ; Global Alliance to Am J Obstet Gynecol. 2018 Mar;218(3):345.e1-345.e30. doi:10.1016/j.ajog.2017.12.234. Epub 2018 Jan 2. PubMed PMID: 29305255

A wellness study of 108 individuals using personal, dense, dynamic data clouds.  Price ND, Magis AT, Earls JC, Glusman G, Levy R, Lausted C, McDonald DT, Kusebauch U, Moss CL, Zhou Y, Qin S, Moritz RL, Brogaard K, Omenn GS, Lovejoy JC, Hood L. Nat Biotechnol. 2017 Aug;35(8):747-756. doi: 10.1038/nbt.3870. Epub 2017 Jul 17. PMID: 28714965

Big biomedical data as the key resource for discovery science. Toga AW, Foster I, Kesselman C, Madduri R, Chard K, Deutsch EW, Price ND, Glusman G, Heavner BD, Dinov ID, Ames J, Van Horn J, Kramer R, Hood L. J Am Med Inform Assoc. 2015 Nov;22(6):1126-31. doi: 10.1093/jamia/ocv077. Epub 2015 Jul 21. PMID: 26198305

Featured Projects

  • Manifestation of Polygenic Risk Scores

    Transitions from health to disease are characterized by dysregulation of biological networks under the influence of genetic and environmental factors, often over the course of years to decades before clinical symptoms appear. Understanding these dynamics has important implications for preventive medicine. However, progress has been hindered both by the difficulty of identifying individuals who will eventually go on to develop a particular disease, and by the inaccessibility of most disease-relevant…