Noa Rappaport, PhD

Research Scientist

Computational Biology

I received my Bachelor’s degree in Biology under the Technion Excellence Program in Israel. I did My masters and PhD  with Prof. Naama Barkai at the Weizmann Institute of Science in Israel. The focus of my masters was mathematical models in yeast of biological timers and robust gradient detection.  My PhD was focused on studying the evolution of anti-fungal drug resistance.

During my post-doc at the lab of Prof. Doron Lancet at the Weizmann Institute of science, I led the development of MalaCards – an integrated database of human diseases.

My main interest is systems biology with the long-term goal to study how concepts such as control, regulation, program and function, emerge in complex biological systems. I am mainly interested in applying and developing mathematical methodologies and bioinformatic tools for studying the design principles of biological systems. Also, I am interested to study how intricate web of interactions (among cellular components, among diseases etc.) affect function and how the network can be controlled by cellular context in a way that can be utilized for medical applications.

  • Bioinformatics
  • Mathematical Modelling
  • Medical databases
  1. The ups and downs of biological timers. Rappaport, N., Winter, S. and Barkai, N. (2005), Theoretical Biology and Medical Modeling.
  2. Disentangling signaling gradients generated by equivalent sources. Rappaport, N. and Barkai, N. (2012), Journal of Biological Physics 38(2): 267-278.
  3. Non-redundant compendium of human ncRNA genes in GeneCards. Belinky F, Bahir I, Stelzer G, Zimmerman S, Rosen N, Nativ N, Dalah I, Iny Stein T, Rappaport N, Mituyama T, Safran M, Lancet D. (2013), Bioinformatics 29(2): 255-261.
  4. MalaCards: an integrated compendium for diseases and their annotation. Rappaport, N., Nativ, N., Stelzer, G., Twik, M., Guan-Golan, Y., Stein, T. I., Bahir, I., Belinky, F., Morrey, C. P., Safran, M. et al. (2013), Database-Oxford.
  5. An Overview of Synergistic Data Tools for Biological Scrutiny. Olender T, Safran M, Edgar R, Stelzer G, Nativ N, Rosen N, Shtrichman R, Mazor Y, West M D, Keydar I, Rappaport N, Belinky F, Warshawsky D, and Lancet D. (2013), Israel Journal of Chemistry, Volume 53, Issue 3-4, pages 185–198.
  6. MalaCards: A Comprehensive Automatically-Mined Database of Human Diseases. Rappaport, N., Twik, M., Nativ, N., Stelzer, G., Bahir, I., Stein, T. I., Safran, M. and Lancet, D. (2014), Current Protocols in Bioinformatics, 47:1.24:1.24.1–1.24.19.
  7. The GeneCards Suite: From Gene Data Mining to Disease Genome Sequence Analysis. Stelzer, G., Rosen, N., Plaschkes, I., Lieder, I., Zimmerman, S., Twik, M., Fishilevich, S., Nudel, R., Koh, A., Mazor, Y., Kaplan, S., Iny Stein, T., Warshawsky, D., Guan-Golan, Y., Rappaport, N., Safran, M. and Lancet,D. Current Protocols in Bioinformatics (2016), 54:1.30.1-1.30.33. doi: 10.1002/cpbi.5.
  8. Rational confederation of genes and diseases: NGS interpretation via GeneCards, MalaCards and VarElect. Rappaport, N., Twik, M., Belinky, F., Plaschkes, I., Stelzer, G., Nudel, R., Iny Stein, T., Oz-Levi, D., Cohen, D., Fishilevich,  S., Safran, M. and Lancet, D. (2017). In Press.
  9. VarElect: the phenotype-based variation prioritizer of the GeneCards suite. Stelzer, G., Plaschkes, I., Oz-Levi, D., Alkelai, A., Olender, T., Zimmerman, S., Twik, T., Belinky, F., Fishilevich, S., Nudel, R., Guan-Golan, Y., Koh, A., Mazor, Y., Kaplan, S., Iny Stein, T., Baris, H., Rappaport, N., Safran, M. and Lancet,D. BMC Genomics (2016), 17(Suppl 2):444; DOI: 10.1186/s12864-016-2722-2.
  10. GeneAnalytics: An integrative gene set analysis tool. Ben-Ari Fuchs, S., Lieder,I., Stelzer, G., Mazor, Y., Buzhor, E., Kaplan, S.,  Bogoch,Y., Plaschkes,I., Shitrit, A., Rappaport, N., Kohn, A., Edgar, R., Shenhav, L., Safran, M.,  Lancet,D., Guan-Golan,Y., Warshawsky,D., Strichman,R. (2016), OMICS, 20, 139-151.
  11. MalaCards: an amalgamated human disease compendium with diverse clinical and genetic annotation and structured search. Rappaport, N., Twik, M., Plaschkes, I., Nudel, R., Iny Stein, T., Levitt, J., Gershoni, M., Morrey, C. P., Safran, M., and Lancet, D. Nucleic Acids Research (2016), doi: 10.1093/nar/gkw1012.
  12. GeneHancer: a comprehensive database of annotated human enhancers, key to interpreting intergenic regions in whole genome sequences. Fishilevich,  S., Nudel, R., Rappaport, N., Cohen, D., Safran, M.,  and Lancet, D. Database (Oxford) (2017), doi:10.1093/database/bax028.