News

Dr. Nathan Price at the Vancouver Bioinformatics Users Group 2012: “Integrated modeling of metabolic and regulatory networks”

In this presentation at the the Vancouver Bioinformatics Users Group from 2012, Nathan Price  discusses approaches for the creation of quantitative systems models that can harness the power of genomics, by linking genotype to phenotype. The talk focuses particularly on automated methods for integrating metabolic and regulatory networks, such as Probabilistic Regulation of Metabolism (PROM) (Chandrasekaran and Price, PNAS, 2010). PROM is notable in that it represents the successful integration of a top-down reconstructed, statistically inferred regulatory network with a bottom-up reconstructed, biochemically detailed metabolic network, bridging two important classes of systems biology models that are rarely combined quantitatively. A strategy to curate the inference of regulatory interactions from high throughput data using metabolic networks is discussed—providing multiple layers of biological context to the problem of regulation. Finally, an approach for building tissue and cell type specific metabolic models is also presented, applied to 131 different cell types and tissues in the human body.

The Vancouver Bioinformatics Users Group (VanBUG) is an association of Bioinformatics enthusiast in the B.C. Lower Mainland, Canada.

Recent Articles

  • Fireside Chat with NIH Director Francis Collins and ISB Co-founder Dr. Lee Hood

    ISB Co-founder Dr. Lee Hood hosted a fireside chat with NIH Director Dr. Francis Collins. The renowned scientists talked about their early careers and long friendship, the challenge of COVID-19, the preceding scientific work that led to the fast development of COVID vaccines, and much more.

  • Coaching for Cognition in Alzheimer’s (COCOA) Clinical Trial Nearly Complete

    The multi-year Coaching for Cognition in Alzheimer’s (COCOA) clinical trial is nearly complete. The trial examined diet, exercise and cognitive training as possible non-pharmacological interventions to Alzheimer’s, with some trial members receiving telephonic coaching centered on stress, diet and exercise, as well as brain training focusing on brain speed and attention.

  • A New Approach to Alzheimer’s Disease

    The impact of Alzheimer’s Disease is staggering – 6 million Americans diagnosed, a financial toll of $600 billion annually, and no effective drug treatments. ISB Co-founder Dr. Lee Hood said the traditional approach isn’t working, and we need to think about it in brand new ways.